Guey-Jen Lee-Chen Selected Research

Gait Ataxia

7/2020	Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases.
4/2015	Trehalose attenuates the gait ataxia and gliosis of spinocerebellar ataxia type 17 mice.

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Guey-Jen Lee-Chen Research Topics

Disease

24	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 11/2020 - 10/2008
22	Parkinson Disease (Parkinson's Disease) 03/2021 - 02/2004
14	Alzheimer Disease (Alzheimer's Disease) 07/2022 - 03/2010
14	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2022 - 01/2013
8	Inflammation (Inflammations) 03/2021 - 05/2013
7	Neuroblastoma 07/2022 - 01/2009
7	Neuroinflammatory Diseases 03/2021 - 01/2018
5	Huntington Disease (Huntington's Disease) 01/2016 - 01/2013
4	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2019 - 01/2013
3	Dementia (Dementias) 06/2019 - 01/2007
3	Parkinsonian Disorders (Parkinsonism) 01/2018 - 03/2010
3	Cerebral Hemorrhage 10/2012 - 10/2009
2	Gait Ataxia 07/2020 - 04/2015
2	Cognitive Dysfunction 02/2019 - 01/2012
2	Disease Progression 01/2019 - 06/2004
2	Amyloid Plaque 12/2018 - 02/2016
2	Tauopathies 01/2016 - 01/2016
2	Cerebellar Ataxia (Dysmetria) 01/2016 - 12/2014
2	Atrophy 06/2014 - 10/2004
2	Hypertension (High Blood Pressure) 10/2012 - 04/2004
2	Spinocerebellar Ataxia 17 01/2012 - 02/2009
2	Vesico-Ureteral Reflux (Vesicoureteral Reflux) 06/2004 - 04/2004
1	B-Cell Lymphoma (Lymphoma, B Cell) 11/2021
1	Neuritis (Polyneuritis) 01/2020
1	Hypoxia (Hypoxemia) 01/2020
1	Ataxia (Dyssynergia) 01/2019
1	Frontotemporal Dementia (Semantic Dementia) 01/2018

Drug/Important Bio-Agent (IBA)

19	polyglutamineIBA 03/2021 - 02/2009
14	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2020 - 02/2009
13	tributyl phosphate (TBP)IBA 01/2020 - 10/2005
12	Proteins (Proteins, Gene)FDA Link 07/2020 - 04/2008
7	Amyloid (Amyloid Fibrils)IBA 01/2021 - 02/2016
5	MelibioseIBA 03/2021 - 05/2015
5	Lactulose (Duphalac)FDA LinkGeneric 03/2021 - 05/2015
5	Pharmaceutical PreparationsIBA 01/2021 - 08/2008
5	tau Proteins (tau Protein)IBA 01/2021 - 01/2016
4	Brain-Derived Neurotrophic Factor (BDNF)IBA 11/2021 - 06/2007
4	TrehaloseIBA 03/2021 - 04/2015
4	SynucleinsIBA 01/2021 - 03/2016
4	indoleIBA 01/2019 - 08/2008
3	Phosphotransferases (Kinase)IBA 07/2022 - 01/2013
3	Neuroprotective AgentsIBA 03/2021 - 01/2007
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 04/2007
3	glycyrrhizae radix et rhizomaIBA 01/2021 - 01/2018
3	Peptide Initiation Factors (Initiation Factor)IBA 01/2020 - 03/2010
3	TrehalaseIBA 01/2020 - 05/2015
3	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019 - 07/2010
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 07/2022 - 11/2021
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2021 - 01/2016
2	Apolipoproteins E (ApoE)IBA 01/2019 - 10/2009
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 01/2014
2	UbiquitinIBA 01/2019 - 07/2010
2	EnzymesIBA 06/2016 - 06/2002
2	Transcription Factors (Transcription Factor)IBA 01/2016 - 04/2015
2	Protein Kinases (Protein Kinase)IBA 09/2015 - 10/2012
2	AtaxinsIBA 01/2013 - 02/2009
2	Leucine (L-Leucine)FDA Link 01/2013 - 01/2011
2	CholesterolIBA 10/2012 - 10/2009
2	LipidsIBA 01/2011 - 10/2009
2	LuciferasesIBA 05/2009 - 01/2009
2	Biological ProductsIBA 10/2008 - 08/2008
2	DNA (Deoxyribonucleic Acid)IBA 01/2007 - 10/2003
1	Glycogen Synthase (Synthase I)IBA 07/2022
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 11/2021
1	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 11/2021
1	CoumarinsIBA 11/2021
1	PrebioticsIBA 03/2021
1	InterferonsIBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2021
1	coumarinIBA 01/2021
1	Chalcone (Benzalacetophenone)IBA 01/2021
1	6,7-dihydroxyflavoneIBA 01/2021
1	ApigeninIBA 01/2021
1	wogoninIBA 01/2021
1	FlavonesIBA 01/2021
1	QuercetinIBA 01/2021
1	AntioxidantsIBA 11/2020
1	trkB ReceptorIBA 10/2020
1	PHA 767491IBA 07/2020
1	IronIBA 01/2020
1	Oxygen (Dioxygen)IBA 01/2020
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2020
1	Hypoxia-Inducible Factor 1IBA 01/2020
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2020
1	N-(4-hydroxyphenyl)arachidonylamide (AM404)IBA 02/2019
1	NC009-1 compoundIBA 01/2019
1	AcetylcholinesteraseIBA 01/2019
1	Dinoprostone (PGE2)FDA Link 10/2018
1	Free RadicalsIBA 01/2018
1	Plant ExtractsIBA 01/2018
1	Complementary DNA (cDNA)IBA 01/2018
1	CytokinesIBA 01/2018
1	ProgranulinsIBA 01/2018
1	F-Box ProteinsIBA 11/2016
1	Glycogen Synthase KinasesIBA 06/2016
1	Ginkgo biloba extract (Rokan)IBA 01/2016
1	Terpenes (Terpenoids)IBA 01/2016

Therapy/Procedure

4	Therapeutics 01/2021 - 01/2019
2	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2019 - 01/2016